ENVIRONMENTAL TOXICOLOGY (EHSC 4490)
Department of Environmental Health Science
Environmental Health Science Building
University of Georgia
Instructor:
Mary Alice Smith, Ph. D.
Office: 202 Environmental Health Science Building
Email: masmith@uga.edu
Phone: (706) 542-1599
Office Hours: Tuesday 2:00-4:30; Wednesday 3:00-5:00, or by appointment
Description: A study of the extent and significance of toxic agents in the environment and the biological processes which determine their behavior, fate, and ultimate effect on human health.
Credit: 3 hours
Prerequisite: CHEM 2211, 2211L or permission of department
Meeting Time: Tuesday/Thursday 11:00-12:15
Meeting Location: Room 101, Environmental Health Science Building
Required Text: Casarett and Doull's Essentials of Toxicology , C.D. Klassen and J.B. Watkins III, editors. 2003. Publisher: The McGraw-Hill Companies, Inc.
Course Policies:
Attendance: Regular attendance is expected of all students at all classroom sessions. In the event of your absence, you are held responsible for all material covered or assigned during class. Make-up exams will not be given, but a comprehensive final exam will be used for the missed exam.Assignments: Handouts and problem sets will be given out during class at various times during the quarter. You are expected to read the handouts and to work the problems and turn in the answers to the problems by the due date.
Grades: There will be 3 in class exams and a final exam. There will also be a risk assessment project worked in groups. The grading will be as follows:
Exam 1 = 20%
Exam 2 = 20%
Exam 3 = 20%
Final Exam = 20%
Project = 15%
Homework = 5%
| Date | Topic | Assignments |
| 1. General Principles of Toxicology | ||
| Aug 19 Th | Introduction to Toxicology | Chapt 1 |
| Aug 24 T | Principles of Toxicology | Chapt 2 |
| Aug 26 Th | Absorption and Distribution of Toxicants | Chapt 5, 59-67 |
| Aug 31 T | Storage and Excretion of Toxicants | Chapt 5, 67-70 |
| Sept 2 Th | Biotransformation of Toxic Chemicals - Phase I | Chapt 6, 71-88 |
| Sept 7 T | Biotransformation of Toxic Chemicals - Phase II | Chapt 6, 88-97 |
| Sept 9 Th | Mechanisms of Toxic Effects | Chapt 3 |
| Sept 14 T | Factors Modifying Metabolism and Toxicokinetics | Chapt 7 |
| Sept 16 Th | Exam I | |
| 2. Organ Specific Toxicology | ||
| Sept 21 T | Mutagenesis | Chapt 9 |
| Sept 23 Th | Carcinogenesis | Chapt 8 |
| Sept 28 T | Liver Toxicology | Chapt 13 |
| Sept 30 Th | Renal Toxicology and Immunotoxicology | Chapt 14 & 12 |
| Oct 5 T | Neurotoxicology and Toxicology of the Eye | Chapt 17 |
| Oct 7 Th | Inhalation Toxicology | Chapt 15 |
| Oct 12 T | Cardiovascular Toxicology and Dermatoxicology | Chapt 18 & 19 |
| Oct 14 Th | Reproductive and Endocrine Toxicology | Chap 29 & 21 |
| Oct 19 | Developmental Toxicology | Chapt 10 |
| Oct 21 Th | Exam 2 | |
| 3. Assessment of Toxicology | ||
Oct 26 T |
Overview of risk assessment projects | Handouts |
| Oct 28 Th | Fall Break | |
| Nov 2 T | Risk Assessment - Hazard Evaluation and Exposure Assessment | Chapt 4 |
| Nov 4 Th | Pesticides | Chapt 22 |
| Nov 9 Tu | Risk Assessment - Toxicity Assessment and Risk Characterization | Chapt 4 |
| 4. Classes of Toxic Chemicals | ||
| Nov 11 Th | Volatile Organic Compounds and Solvents | Chapt 24 |
| Nov 16 T | Metals and Radionucleotides | Chapt 23 & 25 |
| Nov 18 Th | Exam 3 | |
| Nov 23 T | 'Natural' Toxins | Chapt 26 & 27 |
| Nov 25 Th | Thanksgiving Day | |
| Nov 30 T | Ecotoxicology | Chapt 29 |
| Dec 2 Th | Food Toxicology | Chapt 30 |
| Dec 7 Tu | Friday Class Schedule | |
| Dec 9 Th | Toxic Chemicals in the air, soil and water | Chapt 28 and Handouts |
| Dec 14 T
Final Exam |
12:00 - 3:00 pm. Will be in two parts. First section will cover the last section of material and is required of all students; the second section will be optional and can be used to drop a lower grade or is a makeup exam for any exam missed. Second section is a comprehensive exam. | |